RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-29a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; Masson's trichrome staining etc.
Target
TGFB;FOS;SMAD2;SMAD3;COL1A1;COL3A1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Effects of miR-29a and miR-101a Expression on Myocardial Interstitial Collagen Generation After Aerobic Exercise in Myocardial-infarcted Rats
Year
2017
Function
Aerobic exercise can inhibit TGF-beta pathway via up-regulation to the expression of miR-29a and miR-101a and finally cause a reduced fibrosis and scar formation in cardiac tissue.